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High-Throughput Screening Knowledge Center

 Overview of Services

HTSKC RRID: SCR_023235

The High-Throughput Screening KnowledgeCenter's mission is to provide researchers at Stanford with the ability to run high-throughput chemical, siRNA, cDNA, and high-content screens for the purpose of drug and/or target discovery. The HTSKC is a Sarafan ChEM-H Stanford University core facility and was originally created in 2003 by the Department of Chemical and Systems Biology (formerly Molecular Pharmacology). The HTSKC is a shared resource (Bioscience Screening Facility) for the Stanford Cancer Institute. 

 This high-throughput screening (HTS) laboratory allows Stanford researchers and others to discover novel modulators of targets that otherwise would not be practical in industry. The center incorporates instrumentation (purchased with NCRR NIH Instrumentation grant numbers S10RR019513, S10RR026338, and S10OD025004), databases, compound libraries, and personnel whose previous sole domains were in industry. Among our instrumentation are a Molecular Devices ImageXpress Micro High-Content fluorescence microplate imager, with live cell and phase contrast/brightfield options, a Caliper Life Sciences SciClone ALH3000 and an Agilent Bravo microplate liquid handler, and the Tecan Infinite M1000 and M1000 PRO and Molecular Devices Analyst GT and FlexStation II 384 fluorescence, luminescence and absorbance multimode microplate readers. We have over 130,000 small molecules for compound screens, 15,000 cDNAs for genomic screens, and whole genome siRNA libraries targeting the human genome (the siARRAY whole human genome siRNA library from ThermoFisher Scientific, formerly Dharmacon, targeting 21,000 human genes) and the mouse genome (Qiagen mouse whole genome siRNA set V1 against ~17,000 genes). NEW for 2018, Union Biometric BioSorter** Automated Large Object Sorter (FACS) for 10-200 micron objects such as large cells and C. elegans .
HTBC Lab IX Micro Staccato

 Getting Started

 Leadership

 Bruce Koch, Ph.D. | HTSKC Director

Phone:  (650) 724-1835

Email:  bkoch at stanford.edu

 

David E. Solow-Cordero, Ph.D. | HTSKC Associate Director

Phone:  (650) 725-6002

Email:  desolow at stanford.edu

 

 Professor James K. Chen, Ph.D. | Faculty Advisor Co-Director HTSKC

 Location and Hours of Operation

Location

Hours

High-Throughput Screening Knowledge Center

Stanford University ChEM-H

Sarafan ChEM-H W008

290 Jane Stanford Way

Stanford, CA 94305

 

HTSKC CCSR lab

Stanford University Medical Center

CCSR Room 0133 - North Wing

269 Campus Dr.

Stanford, CA 94305-5174

 

 

9 a.m. - 6 p.m., Monday to Friday  

24/7 access for trained users

 

 

 Directions:

 The HTSKC labs are located in Room W008 of the Sarafan ChEM-H building and Room 0133 (basement) of the CCSR building North Wing-Green Walls (269 Campus Dr. West).

 

Directions | Campus Map  | Parking Map; Metered parking spots in L-16 & L-17, free parking anywhere after 4 PM.

Links and Resources

 Visit our core website for more information:  https://med.stanford.edu/htbc.html/

Publication Acknowledgement

 As with all Stanford Service Centers, credit must be given to Sarafan ChEM-H High-Throughput Screening Knowledge Center for data that results in a publication. If the work done at High-Throughput Screening Knowledge Center produces data resulting in a figure in a publication, you are required to acknowledge HTSKC in the publication. Further, if HTSKC staff members provided significant experimental design, data interpretation, or other intellectual contribution (as evaluated by the PI), then it is expected that these individuals will be coauthors on the publication.

Contacts

Name Role Phone Email Location
David Solow-Cordero, Ph.D.
Associate Director, HTSKC
 
650 725-6002
 
desolow@stanford.edu
 
CCSR 0133A
 
Jason Wu
HTSKC CCSR Research Assistant
 
(650) 725-6004; Lab: (650) 736-7638; HT Imaging Rm: (650) 736-0084
 
jjwu@stanford.edu
 
CCSR 0133
 
Bruce Koch
Director, HTSKC
 
650-724-1835
 
bkoch@stanford.edu
 
ChEM-H W008
 
Oliver Hamto
HTS Automation Specialist
 
(650) 497-8018
 
ohamto@stanford.edu
 
ChEM-H W008
 
Corey Liu
ChEM-H Operations
 
(650) 724-7445
 
liuc@stanford.edu
 
ChEM-H N135D
 
Chris Caridi
HCS Scientist
 
(6500 725-6002
 
ccaridi@stanford.edu
 
CCSR 0133A
 

Fixed Cost Services


Search available services: View: by category alphabetically
Consulting Services (3)
High-Throughput Screening Services (3)

Available Equipment and Resources

Detection Systems (3)
Imaging Systems (3)
Integrated Robotic Systems (3)
Liquid Handling Systems (6)