Biomaterials and Advanced Drug Delivery (BioADD) Laboratory

 

 

              

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Overview of Services

 

The Biomaterials and Advanced Drug Delivery (BioADD) Laboratory is a cutting edge research facility founded in 2010 on the Stanford University Medical Campus. Today’s problems in drug design require complex answers to achieve effective delivery and treatment. The Stanford BioADD Lab helps to solve these problems with advanced modern technology and innovative solutions. Specializing in the creation of biomaterials and drug delivery agents, the lab lends its expertise toward designing and analyzing biomaterials, developing drug delivery devices and formulations, pharmacokinetic and pharmacodynamic studies, and developing smart materials for biomedical applications. 

 

 

Services

 

Formulation:

  • Developing formulations for drug delivery systems.
  • Development and testing of various types of pharmaceutical and biopharmaceutical formulations; suspensions, injectable, immediate release and controlled drug delivery systems - extended release tablets and transdermal patches.


Biophysical characterization:

  • Study of interactions between proteins and small molecules.
  • Linking pharmaceutical compounds to biopolymers for sustained/targeted delivery.
  • Distribution of drug molecules in a film/patch and gels formulations by Raman mapping.
  • Self-assembly and aggregation of peptide, proteins and other biomolecules.
  • Morphological and surface characterization by AFM, TEM, SEM.
  • Conformational studies on peptides and proteins.
  • Mapping drug molecules in tissue samples by MALDI.


Multi-step organic synthesis:

  • Synthesis, purification and characterization of small molecule compounds
  • Scaled up large scale of intermediates and small molecule compounds and libraries synthesis
  • Microwave assisted chemistry and application of this tool in multi-step and parallel synthesis of diversified chemicals
  • Synthesis, purification and characterization of natural and unusual amino acid derivatives and peptides via solution and solid phase methods


Materials synthesis Characterization:

  • Studying polymorphic conversions of potential new drug substances in different matrices of excipients and polymers.
  • Developing analytical methods for testing of polymorphic purity of various drug substances.
  • Physicochemical characterization of pharmaceuticals and biopharmaceuticals protein binding studies
  • Characterization of reference standards


Bioanalytical division:

  • Analytical method development, optimization and validation.
  • Development of quantitative methods for evaluating performance and efficacy of various types of drug products;development of impurity, content uniformity, strength, identity, residual solvents, water content, release rate, chiral purity assays.
  • Thermodynamic solubility, pH solubility, moisture sorption, skin flux, slurry amplification, compatibility, stability, forced degradation studies, dissolution testing, measurements of pKa, logP, surface area, porosity and density.
  • Supporting lead optimization process and preclinical development of potential new drug product candidates.

 

 

Getting Started

 

  • Stanford Users:  LOGIN or REGISTER for an iLab account using valid Stanford credentials (SUNet ID).


 

 

  

Leadership

 

Jayakumar Rajadas, Ph.D. | BioADD Director

Phone:  650.724.6806

Email:  jayraja at stanford.edu

 

 

Staff

 

Name

Role

Email

 

 

 

Mansi Parekh, Ph.D.

Postdoctoral Scientist parekhmb at stanford.edu

Mohammed Inayathullah, Ph.D.      

Senior Research Scientist

inayath at stanford.edu

Andrey Malkovskiy, Ph.D.

Postdoctoral Scientist

andreym at stanford.edu

Wenchao Sun, PhD

Postdoctoral Scientist

wsun2 at stanford.edu

     
     
     

Venkata Raveendra Pothineni, PhD

Postdoctoral Scientist

pothinen at stanford.edu

     

Kwang Min Kim, PhD

Postdoctoral Scientist

kwangmin at stanford.edu

Hongxiang (Sean) Tang, MS

Research Scientist

seantang2011 at gmail.com

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 



 

Location and Hours of Operation

 

Location

Hours

Stanford BioADD Laboratory

1050 Arastradero Road

Building A, Room A163

Stanford, CA 94304

Lab Phone:  (650) 724-7710

Fax:  (650) 736-2432

9 a.m. - 5 p.m., Monday to Friday  

24/7 access for trained users

 



 

Links and Resources

 

    

 

Publication Acknowledgement

 

As with all Stanford Service Centers, credit must be given to Biomaterials and Advanced Drug Delivery (BioADD) Laboratory for data that results in a publication. If the work done at BioADD produces data resulting in a figure in a publication, you are required to acknowledge BioADD in the publication. Further, if BioADD staff members provided significant experimental design, data interpretation, or other intellectual contribution (as evaluated by the PI), then it is expected that these individuals will be coauthors on the publication.

 

 

Service Agreement and Disclaimers

 

This Agreement sets forth the complete and final agreement between BioADD Center and Client/ collaborators and supersedes and terminates all prior agreements, discussion and understandings, written or oral. During the term of this Agreement, BioADD Center agrees to maintain any and all Confidential Information in strict confidence and not to disclose it outside BioADD Center, provided that the Confidential Information is clearly labeled in advance as confidential. If the Confidential Information is provided verbally, the disclosure of the information will summarize the verbal disclosure in a written document marked confidential and provide it in this form to BioADD Center. For all BioADD Center projects involving animals subjects, the Client/collaborators must annually provide the BioADD Center with copies of their current APLAC approval letter. BioADD Center is not responsible for obtaining approval or retaining such records. The study will be performed and a report will be sent by email to recipient within 14 days of the termination of study. Client/collaborators will receive a copy of original data for the study, and the original data will be stored on BioADD premises.

 

If the work done with this Service Center produces data results in a figure in a publication, you are required to acknowledge the Service Center ("Stanford BioADD") in the publication. Further, if staff members of the center provided significant experimental design, data interpretation, or other intellectual contribution (as evaluated by the PI), then it is expected that these individuals will be coauthors on the publication.

 

The Clients/collaborators acknowledge ultimate responsibility for their own research. STANFORD HEREBY EXPRESSLY DISCLAIMS AND EXCLUDES ALL REPRESENTATIONS AND WARRANTIES CONCERNING STANFORD EQUIPMENT, FACILITIES OR SERVICES. STANFORD DOES NOT GUARANTEE THE ACCURACY OR SUCCESS OF ANY PROJECT. CLIENT/COLLABORATOR ACCEPTS ALL RESULTS IN "AS IS" CONDITION.

 

 

Contacts

Name Role Phone Email Location
Jayakumar Rajadas, Ph.D.
Director
 
650.724.6806
 
jayraja@stanford.edu
 
1050 Arastradero, A148
 

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