Biomaterials and Advanced Drug Delivery (BioADD) Laboratory

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Overview of Services

Services

Formulation:

• Developing formulations for drug delivery systems.
• Development and testing of various types of pharmaceutical and biopharmaceutical formulations; suspensions, injectable, immediate release and controlled drug delivery systems - extended release tablets and transdermal patches.

Biophysical characterization:

• Study of interactions between proteins and small molecules.
• Linking pharmaceutical compounds to biopolymers for sustained/targeted delivery.
• Distribution of drug molecules in a film/patch and gels formulations by Raman mapping.
• Self-assembly and aggregation of peptide, proteins and other biomolecules.
• Morphological and surface characterization by AFM, TEM, SEM.
• Conformational studies on peptides and proteins.
• Mapping drug molecules in tissue samples by MALDI.

Multi-step organic synthesis:

• Synthesis, purification and characterization of small molecule compounds
• Scaled up large scale of intermediates and small molecule compounds and libraries synthesis
• Microwave assisted chemistry and application of this tool in multi-step and parallel synthesis of diversified chemicals
• Synthesis, purification and characterization of natural and unusual amino acid derivatives and peptides via solution and solid phase methods

Materials synthesis Characterization:

• Studying polymorphic conversions of potential new drug substances in different matrices of excipients and polymers.
• Developing analytical methods for testing of polymorphic purity of various drug substances.
• Physicochemical characterization of pharmaceuticals and biopharmaceuticals protein binding studies
• Characterization of reference standards

Bioanalytical division:

• Analytical method development, optimization and validation.
• Development of quantitative methods for evaluating performance and efficacy of various types of drug products;development of impurity, content uniformity, strength, identity, residual solvents, water content, release rate, chiral purity assays.
• Thermodynamic solubility, pH solubility, moisture sorption, skin flux, slurry amplification, compatibility, stability, forced degradation studies, dissolution testing, measurements of pKa, logP, surface area, porosity and density.
• Supporting lead optimization process and preclinical development of potential new drug product candidates.

Getting Started

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• Visit the Customer Help Manual for further guidance using iLab's Core Facility Services.

Leadership

Jayakumar Rajadas, Ph.D. | BioADD Director

Phone:  650.724.6806

Email:  jayraja at stanford.edu

Staff

Location and Hours of Operation

Links and Resources

• Visit our website for more information:  http://bioadd.stanford.edu/

Publication Acknowledgement

As with all Stanford Service Centers, credit must be given to Biomaterials and Advanced Drug Delivery (BioADD) Laboratory for data that results in a publication. If the work done at BioADD produces data resulting in a figure in a publication, you are required to acknowledge BioADD in the publication. Further, if BioADD staff members provided significant experimental design, data interpretation, or other intellectual contribution (as evaluated by the PI), then it is expected that these individuals will be coauthors on the publication.

Service Agreement and Disclaimers

This Agreement sets forth the complete and final agreement between BioADD Center and Client/ collaborators and supersedes and terminates all prior agreements, discussion and understandings, written or oral. During the term of this Agreement, BioADD Center agrees to maintain any and all Confidential Information in strict confidence and not to disclose it outside BioADD Center, provided that the Confidential Information is clearly labeled in advance as confidential. If the Confidential Information is provided verbally, the disclosure of the information will summarize the verbal disclosure in a written document marked confidential and provide it in this form to BioADD Center. For all BioADD Center projects involving animals subjects, the Client/collaborators must annually provide the BioADD Center with copies of their current APLAC approval letter. BioADD Center is not responsible for obtaining approval or retaining such records. The study will be performed and a report will be sent by email to recipient within 14 days of the termination of study. Client/collaborators will receive a copy of original data for the study, and the original data will be stored on BioADD premises.

If the work done with this Service Center produces data results in a figure in a publication, you are required to acknowledge the Service Center ("Stanford BioADD") in the publication. Further, if staff members of the center provided significant experimental design, data interpretation, or other intellectual contribution (as evaluated by the PI), then it is expected that these individuals will be coauthors on the publication.

The Clients/collaborators acknowledge ultimate responsibility for their own research. STANFORD HEREBY EXPRESSLY DISCLAIMS AND EXCLUDES ALL REPRESENTATIONS AND WARRANTIES CONCERNING STANFORD EQUIPMENT, FACILITIES OR SERVICES. STANFORD DOES NOT GUARANTEE THE ACCURACY OR SUCCESS OF ANY PROJECT. CLIENT/COLLABORATOR ACCEPTS ALL RESULTS IN "AS IS" CONDITION.

Contacts

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